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Tools designed for user interaction within student community website
Krejčí, Filip ; Vojíř, Stanislav (advisor) ; Hradil, Jiří (referee)
The thesis deals with the design and creation of an appropriate user environment for user interaction on student information sharing portals. Such an environment will allow students to share and draw information, evaluate content, and communicate quickly in the student portal environment. The work also focuses on ways to engage users in activity. The main goal is the design and development of basic components that serve to interact and communicate with users and are suitable for use in student community portals. In order to find the optimal solution, the work includes analysis of community portals and other websites designed to gather information suitable for university students. It also includes defining the requirements for the basic components, based on the analysis of existing pages. Chosen component is a messenger, content rating, comments, and notification system. For the proper functioning, the latest technology and approaches to design and implementation are used in development. These technologies guarantee high-quality optimization, security and, at the same time, do not reduce the resulting functionality and usability of the components. Design and development is introduced in the creation of a new web application Primát.cz. The idea of the project and the vision that should be fulfilled in the future is presented. In addition, there are reasons for the decision to completely redesign the website instead of just updating or partially rebuilding it. The results are the described and detailed functional components and the introduction of their functionality in the environment of Primát.cz.
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Animal models of sporadic form of Alzheimer's disease
Popelíková, Anna ; Stuchlík, Aleš (advisor) ; Telenský, Petr (referee)
Alzheimer's disease is a severe illness affecting the elderly and its incidence increases markedly every year. To date, there is no effective treatment for this condition available, and the precise mechanism of the pathogenesis remains elusive (apart from the identification of certain genetic mutations as causes in a small percentage of cases). Also, no suitable animal model of this disease has been found so far. This paper provides a summary of non-transgenic models currently in use as well as newly introduced adepts, their characteristics and examples of their use in practice. It covers both rodent models mostly generated by external interventions to the brain tissue homeostasis of the experimental animals, and vertebrate species that have been reported to spontaneously develop Alzheimer's disease-like pathology: the so-called 'natural models'. Thus, this review might provide better orientation in the up-to-date progress of research of this disease.
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